Scientific evidence & other references
18 randomized clinical trials, 24 peer reviewed papers, 30 hospitals and clinics, over 100 anesthesiologists trained on the EasyTIVA regulation algorithm framework in private clinics, public and university hospitals in western Europe.
Peer-reviewed clinical evidence
The EasyTIVA regulation algorithm framework has been used across dozens of clinical trials over the years, most of them randomized and multicenter. Over 100 anesthesiologists were trained to use the sedation regulation algorithm. EasyTIVA was often used as an investigative tool — removing human variability to better study and investigate a variety of clinical topics.
Alexandre Joosten, Joseph Rinehart, Aurélie Bardaji, Philippe Van der Linden, Vincent Jame, Luc Van Obbergh, Brenton Alexander, Maxime Cannesson, Susana Vacas, Ngai Liu, Hichem Slama, Luc Barvais
- RCT
1
Feasibility of Fully Automated Hypnosis, Analgesia, and Fluid Management Using 2 Independent Closed-Loop Systems During Major Vascular Surgery: A Pilot Study
- RCT
2
The feasibility of extubation in the operating room after bilateral lung transplantation in adult emphysema patients: an observational retrospective study
3
- RCT
- RCT
5
- RCT
6
- RCT
- RCT
9
10
- RCT
11
- RCT
- MULTICENTER
12
- RCT
13
14
- RCT
- MULTICENTER
- RCT
16
- RCT
- RCT
18
- RCT
19
- MULTICENTER
- RCT
- MULTICENTER
23
24
- RCT
- MULTICENTER
- RCT
15 years of high-quality, multimodal anesthesia data
A rigorously secured clinical data repository comprising over 10,000 sessions of high-quality, multimodal data acquired from a diverse combination of medical devices — including cerebral monitors, infusion pumps, vital signs monitors, pain monitors, and neuromuscular monitors — supplemented by perioperative event records and comprehensive patient file information. The repository encompasses granular data drawn from a broad spectrum of patient demographic profiles and surgical procedures, representing the culmination of 15 years of systematic data collection.
Partnerships, recognition & thought leadership
Industry recognition
A joint initiative between Medsteer R&D and the Massachusetts General Hospital (MGH) MD PnP Lab has been honored with the Best Technology Award at the 2025 Santa Fe, Arizona industry conference.
Medsteer contributed critical software modules designed for feedback-driven sedation management, including the EasyTIVA regulation algorithm framework and the Bissim digital twin module. Through rapid and seamless integration by the MGH MD PnP Lab, the collaboration culminated in a comprehensive evaluation of the technical and regulatory requirements governing the remote control of infusion pumps within a PCLC-based clinical application. This recognition reflects the platform's demonstrated clinical maturity and the rigorous engineering standards underpinning its development.
Reference book
“Closed-loop automation for TCI and TIVA"
Dr Ngai Liu, Medsteer's CTO, authored Chapter 35 of the reference textbook on intravenous anesthesia and target-controlled infusion.
In the news
EasyTIVA used in Hanoï, Vietnam
EasyTIVA featured in international news coverage, demonstrating closed-loop anesthesia use in Vietnam.
Research consortium
SaAMS — Semi-Autonomous Medical Systems initiative
Medsteer is an active member of the SaAMS initiative and providing technology component and sharing expertise as part of the group effort towards semi-autonomous systems.
Press coverage
A new universal protocol to unleash closed-loop IV anesthesia
Medsteer’s R&D featured in Anesthesiology News, integration of infusion pumps into a closed loop system