A dedicated algorithm for a synthetic brain response — the Bissim module, a virtual brain monitor
Human decisions for Propofol and Remifentanil infusions are processed in silico to generate a realistic BIS Index numerical response — a unique pre-validation tool for any sedation regulation algorithm.
BIS simulation
Bissim, an experimental project
- Human decisions for Propofol and Remifentanil infusions are processed in realtime to generate a realistic BIS Index response
- Computational and mathematical modeling tailored and calibrated to mimic the realities of life in the Operating Room
- Acting as a digital twin to the BIS, the Bissim is a unique and powerful in silico pre-validation tool for sedation regulation algorithms
A specular image
A robust foundation of over 80 M datapoints
Validation of a brain monitor simulator requires a pre-validated sedation regulation algorithm — specifically, one that has been rigorously evaluated across large, diverse patient cohorts, including those classified up to ASA IV, and across a comprehensive range of surgical procedures, including organ transplantation
Bissim's responses to virtual infusions have reached a highly realistic level for all patient groups — in-silico sessions are essentially undistinguishable from in-vivo sessions
A visionary initiative by Medsteer's R&D started in 2020, first on display at ASA 2023 San Francisco
A critical tool
Bissim helps bench-test any sedation regulation algorithm
- Access to a sedated human brain under surgical nociceptive stimuli in a laboratory is undoubtedly impossible
- Bissim follows FDA guidelines and recommendations for in-silico computational modeling.
- The EasyTIVA sedation regulation algorithm is pump-agnostic — regulation performance is identical with all commercially available infusion pumps
- User training on assistance from automation for sedation in the operating room is possible
